Re: Are you EQ'ing your amp to your bridge or neck pickup.
On my G&L Legacys, I set the amp up for the bridge clean tone. I want the maximum amount of treble that I need, without being harsh; for a spanky, country twangy guitar tone. The G&Ls have global passive Treble and Bass controls, so I can get just about anything I want from here.
With a Les Paul, I try to go for a good, broad acoustic guitar-like rhythm tone from the middle switch position (both pickups on) with all controls full up, then I adjust the controls as needed.
I use Mesa Boogie amps, so I always have excellent control over my LEAD Channel EQ.
Bill