If you don't know what you're doing you could wind up with the neck at a wrong angle, and much of the useability of the boltneck to me comes from the utility of being able to remove/shim it.
Also know what kind of glue you're using, and remember how much more contact area a "proper" set neck has compared to a strat pocket.
Why do you want to do it? Tonally, there are things that make SO much more of a difference, including a good setup.