I use the same strings on the same scale.
It depends how far down you tune. I rarely go lower than C# and even that's just on occasion. 10s on a short scale will get kind of loose in that tuning anyway, regardless of what way your guitar is strung. Like Empty Pockets said, it really is a subtle difference. You have to be paying attention to notice it. Besides, some guitars just feel looser naturally anyway. Try it out, you might like it. If you don't then it's pretty simple to switch it back.
There's loads of good information in this thread started a while back about this subject:
https://forum.seymourduncan.com/showthread.php?t=190196&highlight=top+wrapping
Pretty much everything you need to know. If you need the cliff notes then check the last paragraph of EPs post. He pretty much nailed it.