I didn't like the ME50 mainly because when you switch patches there's a signal cut for about a quarter of a second.
This is true of mine also. But it's never been a problem for me since I don't use presets. I just work all the knobs in realtime. But a valid concern if that's how you'll use it.
The ME-50 isn't designed to be ran in the effects loop- it is a front end device. It doesn't lend itself well to effects loops.
Thanks guys but way too much hassle for a the few things I need FX for.