I had a Music Man Silhouette Special with three single coils in there and Music Man's "Silent Circuit" which had an inductor wired into the electronics to act as a dummy coil to cancel hum. It worked very well as long as all three pickups were the same polarity, but changing pickups in and out was a pain stuffing all that wiring in there, working around the battery (it was an active system) and making sure my replacement pickups were the correct polarity.
I wound up gutting the guitar are going with Duncan Stacks... I believe I went with two STKS6's in the neck/middle slots and STKS9b in the bridge. I was very happy with that set. No noise whatsoever and almost impossible to tell from a true single, especially live. Much simpler wiring, too.