Re: General Tone Tips
At stage levels you don't necessarily have to go full out with the gain, speaker break up tends to lend to the crunch. I have used tube heads, solid state heads, combos ranging from 1-12 to 4-10s and can tell you that my sound did change, it didn't change all that drastically. While I prefer tube amps in the studio, I usually end up going solid state live (I know you guys can start giving me crap now. I hear it all the time at gigs-kind of amazing that the same guy who will compliment your tone will almost retract that statement when they find out you are playing through a solid state). That choice is mainly because of convenience, and having lost a tube a tube a few times at a gig. So much of your tone comes from your hands that I think if you sound good you'll probably sound good regardless.
With pickups, I have dialed back on output, I currently use a Pearly gates Plus for everything from country to hard rock/metal/instrumental rock and find that it works for me. The big reason for going to a low/med output bucker is that it, to my ears, seems more articulate. That and the fact that with all the gain being built in to amps these days, you really don't need to hit the input that hard.
And just like most everyone has said, guitar lives in the mid frequencies so don't take it out. You are just losing volume. Too much low end kills articulation and sounds woofy (not a word but the best way I can describe too much bass), and too much high end just makes you sound thin. I would have to agree with EVERYONE who stated that what sounds good at bedroom levels probably won't on stage. I found that out when I auditioned for my first band, turned up, and had to re-eq to not sound like a train wrecking into a semi full of running chainsaws. Also boosting frequencies that aren't there tends to sound a lot worse than removing bad frequencies that are.
So anyhow that's the small amount that I've learned over thirty years of playing.