I tried the 59b with an A2 and liked it a little more than the normal A5 59. A little less scooped.
Having said that, the neck and body of my swamp ash Warmoth strat came in last week. My single coils hadn't arrived yet, so I slapped a 59 into a spare pickguard and wired it directly to the output jack. Boy, was it ever twangy! That swamp ash strat will sound great once my single-coils come in...
...I figured the wood + lack of tone and volume controls were making the 59 sound twangy, so I figured I'd switch the A5 magnet for an A2. I took the 59 apart and what did I find? A magnet with a blue line on it ("blue = A2")! I guess I had forgot to put the A5 back in. Just goes to show you how much of a role wood plays in the sound of a guitar (I had earlier tried the A2 and A5 59's in a chambered mahogany strat).
So...A 59 will get you close, and= A2 59 closer. I think a big key is using an old Marshall. Also, keep in mind that Ed used an EQ between his guitar and amp, with the mids boosted and highs and lows cut (which would explain why he can use an ash strat and not sound so twangy, but there is a bit of twang there if you listen for it).
Also, keep in mind that some of his best recording were done with an Ibanez Destroyer. Ed says it was korina, but there is some confusion because Ibanez at some point switched from korina to ash dyed to look like korina.