Re: Is a Difference In Ohms sonically different?
The only way I think you would tell a difference in the two is if the final impedance was mismatched with the amp head. If the amp thinks it got an 8 ohm load, when in reality it's getting four, then it's going to put out more power, leading to higher, brighter tones.
Two 4 ohm speakers wired in series shouldn't sound any different than a pair of 16 ohm speakers wired in parallel. I'd wager that if any differences did occur that they would be measurable only and undetectable by our ears.
I'd suggest sticking with 8 or 16 ohms when running a single cabinet. Now, is this a 212 or a 412 cab? I ask, because if you've got a 412 cab with a final impedance of 4 ohms, it's more than likely got 4 16 ohm speakers loaded, which can be rewired to 16 ohms. A 212 4 ohm cabinet will have a pair of 8s; also rewirable to 16 ohms.