As a general rule as Marshall amps went forward from 1962 they got more aggressive overall.
The JTM-45 is big, warm, round and due to the tube rectifier has a nice soft compression to it, the lows are big, the highs are soft and the mids are slightly pulled back.
The JTM-50 is sort of the same overall vibe and sound but it's a little stronger, has more aggression in the midrange and has a bit of bark that most 45's don't have.
After they they started the 1986/1992 Bass amps and 1987/1959 Lead amps...the preamps in the Bass amps were more or less the same as the earlier JTM-45/50 amps but the lead amps got a push in the upper mids and a trim of the low end.
Keep in mind that they gain was always creeping up in these amps as the years went on and also very note worthy...Marshall was growing as a rapid rate in the early days so they were always running out of parts and using whatever they could get they was as close as they could get. This lead to old Marshall amps being all over the map in terms of overall tone and even thought there are some fairly consistent tonal aspects of the old Marshalls you can get 2 1987 amps made on the same day they might sound rather different.