Given the diameter of the openings and the depth of the ports, these are not tunable openings. The openings will likely cause some cancellation if left open since they are in the front of the cab. If you like I could calculate the frequency of the ports... but it ain't going to be pretty.
Easy... it's gar easier to replace to speakers in an existing 4x12 cab that I never move than it is to build myself a custom 2x12 cab for some drivers I have laying around. Additionally, double the speakers DOES NOT = double the volume. The volume increase between a 4x12 and a 2x12 receiving the same wattage is barely noticable.
Additionally, I did in fact try this over the weekend by removing two original speakers (leaving two in and disconnecting them), and replacing them with a pair of greenbacks. As soon as I digest the tone a little more, I'll let you know what I think.