Except if the guitar has a non typical strings spacing, it makes no difference. A 3 PUs Les Paul of the Norlin era has the same T-Tops in BMN positions, for instance.
But the answer depends on the sound wanted, depending itself of the specs involved and on how the mid pickup is wired.
So: in which kind of guitar do you want 3 humbuckers and what kind of tone do you want from them?