Can't be done, IMO. Not both. Not with humbuckers. Not at rock volumes, meaning any tube amp turned up passed 5. The Searing Lead Tone is no problem: anything from a Seth Lover right up to a Dimebucker can do that. But after volume 5 or 6, I don't think there's a humbucker made that can get a genuinely clear, clean rythym tone. A nice Tele with great pickups, through a Boss DS-1 and a great tube amp almost can...that's why I play Strats and Teles.
Lew