I have a rg7621, I went with a jb in the bridge/59 in the neck combo. I havent looked back since. Great crunch tones, nice cleans...a real versatile setup. One thing I will warn you about, you may or may not have to rout out a little bit of wood in the pup cavity so that they get in low enough, depending on the pup's that came stock on it. I know on mine I had to knock out like 1/8 of an inch, as mine came with the IBZ pups and those things are flat as hell. But trust me bro....the tone you get afterwords is worth it.