I just can't gel with Jazz IIIs. I can't control them the way I do with a standard pick.
I'm the other way around. I'm so used to Jazz III's, regular picks just feel so alien.
My story with Jazz III's is some years ago, I was tired of getting so scrapy/scratchy pick attack from my tone. I don't remember what I was playing at the moment. Must have been a POD XT. But I read online that Jazz III's smooth out the attack, so I figured I'd give the a try.
I struggled at first with the small size, but eventually, I ended up adapting. And they do sound different. More smooth and/or thuddy compared to Tortex. Not night and day, but with tone, I feel every single detail, subtle as it may be, adds up.
I go on an off these days regarding materials With EVH amps (and the EVH amp sim I'm using right now), the regular ones do help tame some of the scrapy-ness that's inherent to those amps. But if I'm using something like a Recto sim, I definitely prefer the tone of Tortex. But rather than using a full-size Tortex, I like the Jazz III Tortex because I realy don't want to have to re-learn how to hold my pick again.
People often say Jazz III picks are "shredder's picks" because "you have more control with them" and whatnot. I don't find that to be the case at all. To me, it's just a matter of what I'm used to. I don't feel like my playing improved at all from using Jazz III's. If anything, it was worse for the time that I was learning how to incorporate them.