Re: 10-52's
That was my go to gauge for a long time these days I'm using 12-56 I kinda made a custom gauge set out of individual strings.
I liked 10-52 because you got the meat of the 52-42-32 on your low strings but you weren't destroying your hands with 11's/12's in your plain steels. My tastes have since changed and I just like really heavy strings because they give me a subjectively better tone for what I play and I prefer the feel.
You will definitely want to adjust your setup for them anytime you use a hybrid gauged set or change gauges you will have to adjust truss rod, string height, and intonation at least ime.
I tend to prefer DR and SIT strings myself. Depending on the guitar Hi Beams, Pure Blues, Power Wounds, or Power Groove.