I like to plug in a Monster 1100 Power Bar surge protecting power strip straight from the wall, and use a Monster 2500 Power Conditioner and ETA PD8 Power Conditioner.. it improved my sound issues fast, no more hum or hiss .
Buy an outlet tester, start from the plug, using that device and work you way from the guitar/ bass, instrument cable, effects pedals, cable running to the amp, the amp cable to the cabinet, if your using amp cabinets .
Get a Power Conditioner, Hum Eliminators, a Buffer, power strips with surge protection and a power supply for your foot pedals with shielded power outlets .
Ebtech Hum Eliminators have gone sky high in recent years, Behringers Hum Eliminating devices have gone up too.
Pyle make a good Hum Eliminator at a reasonable price .