That's not 250K's doing it, it's what you're doing down the signal path to adjust for it. If you have to add what amounts to too-much-treble at the amp, you probably shouldn't have put in a 250K. With 250K's, I also use 9 gauge strings and a pick with pointed, beveled edges. These add some high-end and I still get a sharp, biting sound from my bridge PU's without dialing in an overabundance of treble at the amp. If your using heavy strings and a normal pick, you're going to sound a lot darker than I do. Those are pieces of the puzzle that get overlooked.
Where I want to get a lot of treble is in my neck HB's. I can't stand a warm, muffled neck PU without any bite. Just too smooth and mellow for me. I use assorted trickery (spin-a-split, hybrid coils, and/or 1-meg pots) to boost treble there and get my tones closer to the bridge PU's. I get both PU's to fall in what I consider to be an acceptable range, with neither one too bright or too warm. I don't care what slot a PU is in, it has to be very usable in rhythm and lead.
Lew: I bet one of them mentioned 250K pots and that started the whole thing. But seriously Lew, we have a lot in common, I really do like you and think you know a lot about guitars and music. We have different views on a few minor things, and I don't want to get in arguments over those. Neither one of us comes out of it looking too good. Maybe we can both work on toning down things a bit.