Custom for E or D tunings
Distortion for C or B tunings
Full Shred for B, A or even lower tunings
I think the Custom will sound too fat in that guitar of yours. I dropped one in my Ibanez Saber a while ago (super thin body + tremolo) and it made that skinny thing sound incredibly huge!
The Distortion is the perfect choice for you! It's amazing in warm sounding guitars with fixed bridges and has a really good tightness in lower tunings. It sounds very angry and aggressive so it's not for everyone (but you're not a wimp, are you?

) I am the proud owner of one of those beasts and use it for brutal downtuned madness where both punch and precision are required. I also really like it for soloing since it has a very nice and distinctive character.
The Full Shred is one of the tightest (and brightest) humbuckers ever so it's the perfect choice for thrash and really low tunings.