I love my 1970's Bill Lawrence L-250 pickups on 22 fret S, S, H configured Super Strats, kind of like a Dimarzio YJM (HS4 ) with a PAF sweetness to it. Roll the volume knob down to 6 1/2 or 7 sounds really good with an acoustic simulation or Sitar simulator.
Sounds great when going full distortion, defined , no Mudd.
On 24 fret S, S, H guitars get the Dragon Fire Duo Rail, very similar to the BL L-250.
On H, S, H Super Strats, I prefer the Dimarzio Humbucker from Hell, Seymour Duncan Screamin' Demon or Pearly Gates. They sound amazing with harmonizers, acoustic / sitar simulators .
A recent great discovery, the Dragonfire Modbucker, kind of like a Screamin' Demon with a slight upper mid and bass kick to it, at 11.06k ohms.