easiesty way to start geting close ...
neck humbucker pickup on 22 fret set neck guitar (i get close with both 59s and AIIPs even on bolt-necks), roll the tone knob down to 'taste' ... lean down part way on a wah wah pedal and leave it 'just so' to taste ... overdriven tone on the amp, not too much fizz ... hint of compression (ok, sometimes more than a hint) ... light touch on the strings - he uses 9's i'm pretty sure ...
harder way to get closest ...
real expensive boogies and dumbles with real expensive PRS guitar
have fun
cheers
t4d