If your Amp is Class A/B (most Fenders, Marshalls, and Peaveys) and you don't want to have to rebias your amp everytime you change power tubes, then get a bunch of matched tubes. Otherwise, if you start mixing and matching different power tubes together, your amp's bias may end up being off, resulting in a crappy sound (e.g., distorts too early or too late).
If your amp is Class A (e.g., Vox AC15 and AC30, Matchless, Orange Tiny Terror), then unmatched tubes are fine since these amps do not require biasing.