Slash needs to go seymour duncan :laugh2:
Just kidding - Id second what tone4days said - maybe someone like Kirk Hammet with a 59 (well, he uses Les Pauls now and maybe before he did) but maybe load them with some Seth Lovers instead of whatever he has in them (even instead of the burstbuckers that come with the historic LPs). That with no pedals plugged into a Fender Tweed amp - he probably can play some sick blues if he tried.