First of all, what is the definition of "better" that we are working with here?
Secondly, the answer is 4x12....as many as possible.
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From a purely technical standpoint, the theory says that a 2x10", will behave better acoustically, mechanically, and sonically, BUTTTTT...... the subjective side of things almost unilaterally leads to 2x12".
The stupid stuff:
1. The smaller speakers CAN have their acoustic centers closer together, reducing comb filtering and providing a more predictable coverage pattern.
2. The smaller speakers have less intermodulation on their cone surface, reducing the beaming effect that larger speakers can exhibit.
3. Smaller speakers tend to sound more acoustically accurate. They have less mass, therefore reacting quicker to the incoming signal. This gives them the punch many like.
4. Smaller speakers have a disadvantage on SPL production though. They have less surface area, therefore they don't displace as much air as a larger driver.
5. Smaller speakers have less low end sound reproduction unless the cabinet they are in is tuned very well.
So while in theory, a 10" cabinet should be a sonic improvement, the neurotic nature, and subjective ideals most guitarists have, drive most to go the 12" route ( me included ). I have gotten to mic MANY 10" cabinets and I cannot say that any sounded inferior to a like 12" loaded one, only that they have a sound and it is the guitarist that makes it work or not. What I do find interesting upon reflecting on it, is that most of the bands that I have worked with ( providing sound support for ) that I have truly enjoyed and lauded, used combo's and or dual-driver cabinets loaded with 10" drivers. I would say that it was mostly due to musical genre though. I like southern rock, blues rock, and 70's rock, and most bands that will utilize a Peavey Classic 30, a Princeton, or a Bassman are predominately such the type to do so. So what I like to hear from a band versus what I prefer myself are two different things I guess.
2x8"
I've been having my Carlsbro Sherwood 60R amp at home, with the EHX "allied overdrive" (at full gain)- to play electric- while I get my home studio up and running.
The 8's have a resonant midrange- that gets like, "in between" the 12.". It's a brown, direct sound- and I plan on runnin both amps at home.... at the same time
My design "EGA Jazztone 4x8"" includes 4 8" speakers, in a semi-open back Pine cabinet- with legs ; to keep it off the ground!!
-Erl
I was pleasantly surprised at the response and punch from my 1x10 combo when I got it. It's loud enough to keep up with a drummer on an acoustic kit. When I first got it, I had to turn it down at a gig. This thing gets loud. There is that little bit missing that only a 12" gives. It's not enough to make me want to change anything with it though. It's a Vox AV30 (sadly discontinued).
IMO a large 212 is the best compromise of big tone and portability.
From a purely technical standpoint, the theory says that a 2x10", will behave better acoustically, mechanically, and sonically, BUTTTTT...... the subjective side of things almost unilaterally leads to 2x12".
The stupid stuff:
1. The smaller speakers CAN have their acoustic centers closer together, reducing comb filtering and providing a more predictable coverage pattern.
2. The smaller speakers have less intermodulation on their cone surface, reducing the beaming effect that larger speakers can exhibit.
3. Smaller speakers tend to sound more acoustically accurate. They have less mass, therefore reacting quicker to the incoming signal. This gives them the punch many like.
4. Smaller speakers have a disadvantage on SPL production though. They have less surface area, therefore they don't displace as much air as a larger driver.
5. Smaller speakers have less low end sound reproduction unless the cabinet they are in is tuned very well.
So while in theory, a 10" cabinet should be a sonic improvement, the neurotic nature, and subjective ideals most guitarists have, drive most to go the 12" route ( me included ). I have gotten to mic MANY 10" cabinets and I cannot say that any sounded inferior to a like 12" loaded one, only that they have a sound and it is the guitarist that makes it work or not. What I do find interesting upon reflecting on it, is that most of the bands that I have worked with ( providing sound support for ) that I have truly enjoyed and lauded, used combo's and or dual-driver cabinets loaded with 10" drivers. I would say that it was mostly due to musical genre though. I like southern rock, blues rock, and 70's rock, and most bands that will utilize a Peavey Classic 30, a Princeton, or a Bassman are predominately such the type to do so. So what I like to hear from a band versus what I prefer myself are two different things I guess.

Years ago somebody discovered that a Bandmaster Reverb head was big enough to put two 8"s into.
Makes it a mini combo. Cool mod. I remember seeing those in the 70s.
They were plenty loud too, not just a gimmick.
Nice. When I can, I go a bit bigger. The 2x15 in the photo is part of the guitar rig.I have both. I use an emptied (amp chassis removed) Carvin Bel Air cab (2X12) for my Bandmaster Reverb and I have a Trace Elliott Bonneville 4X10. I removed and replaced the two bottom Celestions for a pair of Weber California Alnicos and the combination of efficiency and magnet pairing is absolutely amazing and in your face.Both of those rigs sound fantastic.