Re: Your favorite VH tone, and what pickups you feel achieve it best?
70% of his tone for the first 4 albums can be had with a cranked (or power-scaled) Plexi with greenbacks (or suitable clones).
I have a 78, but to be honest, it doesn't seem clear enough and is overly hot. Others say it is overly bright, but I had the opposite experience.
I also tried an A2 59/Custom hybrid, and while it nails the tone, it is too hot, which makes it all wrong (well, maybe "all" is a bit of hyperbole, as it nails the frequency response).
I say either some form of A2 PAF (Seth Lover or a 59 with an A2) or an A5 (e.g stock 59) with a midboost (the infamous frown-EQ).
Having said that, the right amp and speakers will get you mostly there, the pickup is a distant 3rd. Heck, even a stock Custom sorta works with the right setup (a JB never works).
...sorry for rambling....