Re: 6550s into EL34 sockets
To the Dr...You will need to have it biased with adjustable bias, but a pot, or variable resistor, allows whom ever is biasing it to adjust the bias more precisely to the exact set of tubes.
A lot of amps don't provide a variable resistor, but use a set resistor, so as long as you use tubes that are the same, or very close to the same, as the amp was designed for, the user doesn't need to worry about it. This is probably why Mesa usually doesn't have adjustable bias.
This is fine as long as you always use nearly identical tubes, but if you want to change tube types, or use tubes of the same type that bias up differently, or you want to try a different bias with your tubes, it's not so great.
Adjustable bias does however, make the user more dependant upon a tech, unless he/she learns how to do it themselves.
Keeping the bias unadjustable prevents the user that doesn't know how, from screwing up the amp, or melting down a set of tubes , and as long as the user can find the same tubes; he/she doesn't need to take it to a tech everytime.