If it's any indication, I picked a Crate Blue Doodoo over the Marshall Valvestate in 2001. I wanted a head and even as bad as the BV-120H was, the Marshall was worse.
The 5751 tube has different requirements to run it at its optimal spec as opposed to a 12AX7. Just as a 12AU7 can be swapped and will function, without actual component changes it will not operate 100% as intended. The Marshall Valvestate uses only 1 X 12ax7 tube in its circuit! Which without actually looking at a schematic, my best guess is that it is run as more of a buffer stage that exists just before the tone stack than an actual gain stage. Because the amp is designed more around IC and transistor based gain stages with diodes being the most likely form of distortion, I wouldn't be surprised if the tube is being run in starved plate mode even. The point being that because the amps has all its value placed in silicon, the tube portion of the circuit may be very finicky and marginal at best. A typical tube amp has an HT supply rail voltage of around 200 - 300 volts for the preamp. This amp very likely wouldn't need an HT rail that runs that hot and is probably rated tight on its current draw capability. A 12AU7 draws almost 10X as much current as a standard 12AX7, and a 5751 also draws more current than a 12AX7 ( I don't recall exactly how much more though ) and this extra draw on the power supply could be what caused your issue? Tube amps are more forgiving because they usually have a stouter or more robust power supply design which can handle a little more draw. And since in a tube amp that extra draw is stolen from the other tubes ( which can tolerate the subsequent voltage drop without issue ) the amp simply sounds or responds differently. In a SS based amp, the other components require a certain current and voltage supply to work, if the voltage is too low ( from excessive current draw ) because the power supply is unable to provide it, the circuit can do all kinds of strange things. In your case buzzing.
While it sounds like this is a necro thread, at least future readers will have some reference. In hybrid amps, run only what the manufacturer suggests. In 99.99% of cases, it will be the same as what was already in there.